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Although the phase III clinical trial was a failure, Neurochlore was able to retrieve data that could be promising. Indeed, we are convinced that Bumetanide works on sub-populations, defined by more specific criteria that were...

IBEN will give a satellite conference at the FENS 2022, an european congress of neurosciences. The conference, which take place on July 7 and 8 at RIVE Montparnasse, will focus on the Neuroarcheology of the...

Short video depicting the hypothesis that autism and developmental disorders are generated in utero and how identification of the alterations they produce will enable their early prediction and novel treatments. https://www.youtube.com/watch?v=qR-yb-mSh8I

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Being born is not easy. Mammals need to pass through the birth canal before coming out into this world, and to do so the head (and whole body) undergoes a harsh squeezing. Thankfully, the newborn...

How is it possible that drugs used to sedate or calm people, called Benzodiazepines, can induce transient awakenings in comatose patients? In our latest Commentary in Translational Medicine Communications Yehezkel Ben-Ari hypothesizes that a dysregulation...

Since our groundbreaking positive results on the use of Bumetanide (a highly selective antagonist of the NKCC1 chloride importer) to treat autism, first in a pilot open trial and then in two double-blind clinical trials,...

Huntington’s disease, a dominant heritable disease that manifests in mid-adulthood, is caused by expansion of a polyglutamine tract within the huntingtin protein (HTT). The mutation leading to the polyglutamine tract confers a toxic gain of...

The activity of the neurotransmitter GABA, the main inhibitory transmitter in the brain, follows a developmental sequence. In early development GABA excites neurons via type A GABA receptors (GABAAR), and later it inhibits them. In...

How does the brain prepare for birth? Several indirect lines of evidence in Humans suggest that the velocity at which the brain grows in utero slows down during the third trimester, a process that will...

Two of the most biologically complex and vulnerable periods are pregnancy and birth. Birth is a stressful event with a release of several stress molecules needed to facilitate the transition of the fetus to extrauterine...

In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl−)i levels, enhances GABAergic inhibition and attenuates electrical and behavioral symptoms of ASD. In an earlier phase 2 trial; bumetanide...

Encourage, support and publicize active, innovative companies that create jobs in the industrial and craft fields, these are the objectives set by the General Council of Bouches-du-Rhône, which has been organizing the Créa 13 prize...

The scientific community agrees on the early origin – fetal and/or early postnatal – of autism. The teams of Yehezkel Ben-Ari (CEO of Neurochlore and Emeritus Research Director at Inserm) at Neurochlore and at the...

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We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment. In...

Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, GABA excites neurons because...

Ionic currents and the network-driven patterns they generate differ in immature and adult neurons: The developing brain is not a "small adult brain." One of the most investigated examples is the developmentally regulated shift of...